The Immuno-regulation Laboratory (LIR) was founded by Rafael Correa Rocha in 2014, as an emerging group within the Gregorio Marañón Health Research Institute (IISGM). In 2016, Marjorie Pion joined the group as principal investigator (PI), incorporating new lines of research also related to immune regulation. Currently, it has a total of 13 investigators, 2 clinical investigators, 2 clinical trial coordinators, and 1 research manager.
The group focuses its research on the study of the immunological mechanisms involved in various diseases related to immune disorders, especially in pediatric patients.
The main focus of our research is the mechanisms of homeostasis and regulation of the immune system, with a special interest in regulatory T cells or Tregs.
Given their suppressive role, Tregs are crucial in the maintenance of immune homeostasis and, therefore, participate in the control of various alterations or pathologies related to the immune system (allergies, autoimmune diseases, transplant rejection, immune hyperactivation in COVID- 19, etc.).
In addition, the group is developing new lines of advanced research such as the genetic modification of immune cells for the development of advanced cellular immunotherapies, or the study of the immunomodulatory potential of exosomes and other extracellular vesicles.