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Beatriz Rodriguez

Low thymic output, peripheral homeostasis deregulation, and hastened regulatory T cells differentiation in children with 22q11.2 deletion syndrome.

Sara Ferrando-Martínez, Raquel Lorente, Dolores Gurbindo, Ma Isabel De José, Manuel Leal, Ma Angeles Muñoz-Fernández, Rafael Correa-Rocha. J Pediatr. 2014 Apr;164(4).Epub 2014 Jan 23. Abstract Objective: To perform an extensive analysis of the immune status of asymptomatic children with the 22q11.2 deletion syndrome, with special emphasis on the regulatory T cells (Treg) population. Study design: Analysis of thymic function, frequency and absolute counts of immune subsets, and phenotype of Treg were performed in 10 asymptomatic children bearing the 22q11.2 deletion and compared with 12 age-matched, healthy children. Results: Children with 22q11.2 deletion syndrome showed a curtailed thymic output, lower T-cell levels, and a homeostatic deregulation in the CD4 T-cell compartment,… Leer más »Low thymic output, peripheral homeostasis deregulation, and hastened regulatory T cells differentiation in children with 22q11.2 deletion syndrome.

Induction of Treg cells after oral immunotherapy in hen’s egg-allergic children.

Victoria Fuentes-Aparicio, Elena Alonso-Lebrero, Lidia Zapatero, Sonsoles Infante, Raquel Lorente, M Ángeles Muñoz-Fernández, Rafael Correa-Rocha. Pediatr Allergy Immunol  2014 Feb;25(1):103-6. Epub 2013 Oct 7. DOI: 10.1111/pai.12137 Induction of Treg cells after oral immunotherapy in hen’s egg‐allergic children – Fuentes‐Aparicio – 2014 – Pediatric Allergy and Immunology – Wiley Online Library

HIV infection of human regulatory T cells downregulates Foxp3 expression by increasing DNMT3b levels and DNA methylation in the FOXP3 gene.

Marjorie Pion, Didiana Jaramillo-Ruiz, Alberto Martínez, M Angeles Muñoz-Fernández, Rafael Correa-Rocha. AIDS 2013 Aug 24;27(13):2019-29.  DOI: 10.1097/QAD.0b013e32836253fd Abstract Objective: Regulatory T cells (Tregs) play an important role in infections modulating host immune responses and avoiding overreactive immunity. The mechanisms underlying their action in HIV-infected patients have not been well established. HIV can infect Treg, but little is known about the effects of the infection on Treg phenotype and function. The objective of this study was to investigate whether in-vitro HIV infection modifies the phenotype and suppressive capacity of Treg cells. Design: Because Treg cells are a subset of CD4 T cells, HIV infection could produce alterations in… Leer más »HIV infection of human regulatory T cells downregulates Foxp3 expression by increasing DNMT3b levels and DNA methylation in the FOXP3 gene.

Oral immunotherapy in hen’s egg-allergic children increases a hypo-proliferative subset of CD4+ T cells that could constitute a marker of tolerance achievement.

Victoria Fuentes-Aparicio, Elena Alonso-Lebrero, Lidia Zapatero, Sonsoles Infante, Raquel Lorente, Ma Ángeles Muñoz-Fernández, Rafael Correa-Rocha. Pediatr Allergy Immunol . 2012 Nov;23(7):648-53. Epub 2012 Jul 26. DOI: 10.1111/j.1399-3038.2012.01333.x Abstract Background: Food allergy affects a significant number of children and its prevalence, and persistence is undergoing an important increase in the last years. Specific oral tolerance induction (SOTI) is a promising therapy for food allergy. However, little is known about the immune mechanisms implicated in the desensitization to allergens. Our purpose was to study which immune parameters are modified during the process of tolerance achievement with the goal of identifying markers of tolerance induction. Methods: We performed… Leer más »Oral immunotherapy in hen’s egg-allergic children increases a hypo-proliferative subset of CD4+ T cells that could constitute a marker of tolerance achievement.