Producción Científica

Induction of High Levels of Specific Humoral and Cellular Responses to SARS-CoV-2 After the Administration of Covid-19 mRNA Vaccines Requires Several Days.

octubre 4, 2021 https://doi.org/10.3389/fimmu.2021.726960

Sergio Gil-Manso, Diego Carbonell, Luis López-Fernández, Iria Miguens, Roberto Alonso, Ismael Buño, Patricia Muñoz, Jordi Ochando, Marjorie Pion and Rafael Correa-Rocha. Front. Immunol., 04 October 2021. ORIGINAL RESEARCH ARTICLE. https://doi.org/10.3389/fimmu.2021.726960 Objectives: In the context of the Covid-19 pandemic, the fast development of vaccines with efficacy of around 95% preventing Covid-19 illness provides a unique opportunity… Leer más »Induction of High Levels of Specific Humoral and Cellular Responses to SARS-CoV-2 After the Administration of Covid-19 mRNA Vaccines Requires Several Days.

Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity.

agosto 4, 2021 DOI: 10.1016/j.celrep.2021.109570

Daniel Lozano-Ojalvo, Carmen Camara  Eduardo Lopez-Granados, Pilar Nozal, Lucía Del Pino-Molina, Luz Yadira Bravo-Gallego, Estela Paz-Artal , Marjorie Pion , Rafael Correa-Rocha , Alberto Ortiz, Marcos Lopez-Hoyos, Marta Erro Iribarren, Jose Portoles, Maria Pilar Rojo-Portoles, Gloria Ojeda, Isabel Cervera, Maria Gonzalez-Perez, Irene Bodega-Mayor, Maria Montes-Casado, Pilar Portoles, Mayte Perez-Olmeda, Jesus Oteo, Rodrigo Sanchez-Tarjuelo, Venu Pothula, Megan Schwarz, Manisha Brahmachary, Anthony Tanoto Tan, Nina Le Bert, Cecilia Berin, Antonio Bertoletti, Ernesto Guccione, Jordi Ochando. Cell Reports 36, 109570 August 24, 2021 DOI: 10.1016/j.celrep.2021.109570 ABSTRACT The rapid development of mRNA-based vaccines against… Leer más »Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity.

The Presence of a Marked Imbalance Between Regulatory T Cells and Effector T Cells Reveals That Tolerance Mechanisms Could Be Compromised in Heart Transplant Children.

abril 23, 2021 DOI: 10.1097/TXD.0000000000001152

Esther Bernaldo-de-Quirós, Jacobo López-Abente, Manuela Camino Nuria Gil, Esther Panadero, Rocío López-Esteban, Marta Martínez-Bonet, Marjorie Pion, Rafael Correa-Rocha. Transplant Direct. 2021 2021 Apr 23;7(5):e693 DOI: 10.1097/TXD.0000000000001152 Abstract Regulatory T cells (Treg) are crucial for the induction and maintenance of graft tolerance. In pediatric heart transplant procedures, the thymus is routinely excised, removing the primary source of T-cell replenishment. Consequently, thymectomy joined to the effects… Leer más »The Presence of a Marked Imbalance Between Regulatory T Cells and Effector T Cells Reveals That Tolerance Mechanisms Could Be Compromised in Heart Transplant Children.

Ectopic FOXP3 Expression in Combination with TGF-β1 and IL-2 Stimulation Generates Limited Suppressive Function in Human Primary Activated Thymocytes Ex Vivo.

DOI: 10.3390/biomedicines9050461

Jorge Gallego-Valle, Sergio Gil-Manso, Ana Pita, Esther Bernaldo-de-Quirós, Rocío López-Esteban, Marta Martínez-Bonet, Verónica Astrid Pérez-Fernández, Ramón Pérez-Caballero, Carlos Pardo, Juan-Miguel Gil-Jaurena, Rafael Correa-Rocha and Marjorie Pion. Biomedicines 2021, 9(5), 461 DOI: 10.3390/biomedicines9050461 Abstract Regulatory T cells (Tregs), which are characterized by the expression of the transcription factor forkhead box P3 (FOXP3), are the main immune cells that induce… Leer más »Ectopic FOXP3 Expression in Combination with TGF-β1 and IL-2 Stimulation Generates Limited Suppressive Function in Human Primary Activated Thymocytes Ex Vivo.

Colchicine treatment in children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome: A multicenter study in Spain.

abril 1, 2021 DOI: 10.5152/eurjrheum.2020.20102

Cristian Quintana-Ortega, Elena Seoane-Reula, Laura Fernández, Marisol Camacho, Peter Olbrich, Olaf Neth, Sara Murias, Clara Udaondo, Agustín Remesal, Cristina Calvo, Rosa Alcobendas. Eur J Rheumatol 2021; 8(2): 73-8 DOI: 10.5152/eurjrheum.2020.20102 Abstract Objective: To evaluate the efficacy of colchicine therapy in pediatric patients with PFAPA syndrome who present with an incomplete response to the standard treatment or… Leer más »Colchicine treatment in children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome: A multicenter study in Spain.

Clinical course of severe patients with COVID-19 treated with tocilizumab: report from a cohort study in Spain.

febrero 1, 2021 DOI:10.1080/17512433.2021.1875819

Esther Chamorro-de-Vega, Carmen-Guadalupe Rodriguez-Gonzalez, Silvia Manrique-Rodríguez, Elena Lobato-Matilla, Felix García-Moreno, Maria Olmedo, Rafael Correa-Rocha, Maricela Valerio, Teresa Aldámiz-Echevarria, Marina Machado, Milagros Sancho-Gonzalez, Juan Carlos Lopez-Bernaldo-de-Quirós, Paula Ruiz-Briones, Rosa Romero-Jiménez, Camino Sarobe-González, Alvaro Gimenez-Manzorro, Roberto Collado-Borrell, Cecilia M Fernandez-Llamazares, Jose Luis Revuelta-Herrero, Beatriz Somoza-Fernandez, Sebastian Garcia-Sanchez, Irene Taladriz-Sender, Emilio Bouza, Ana Herranz, Patricia Muñoz &Maria Sanjurjo. Expert… Leer más »Clinical course of severe patients with COVID-19 treated with tocilizumab: report from a cohort study in Spain.

Coronavirus disease 2019 in patients with inborn errors of immunity: An international study.

DOI: 10.1016/j.jaci.2020.09.010

Isabelle Meyts, Giorgia Bucciol, Isabella Quinti, Bénédicte Neven, Alain Fischer, Elena Seoane, Eduardo Lopez-Granados, Carla Gianelli, Angel Robles-Marhuenda, Pierre-Yves Jeandel, Catherine Paillard, Vijay G Sankaran, Yesim Yilmaz Demirdag, Vassilios Lougaris, Alessandro Aiuti, Alessandro Plebani, Cinzia Milito, Virgil Ash Dalm, Kissy Guevara-Hoyer, Silvia Sánchez-Ramón, Liliana Bezrodnik, Federica Barzaghi, Luis Ignacio Gonzalez-Granado, Grant R Hayman, Gulbu Uzel, Leonardo Oliveira Mendonça, Carlo Agostini, Giuseppe Spadaro, Raffaele Badolato, Annarosa Soresina, François Vermeulen, Cedric Bosteels, Bart N Lambrecht, Michael Keller, Peter J Mustillo, Roshini S Abraham, Sudhir Gupta, Ahmet Ozen, Elif Karakoc-Aydiner, Safa Baris, Alexandra F Freeman, Marco Yamazaki-Nakashimada, Selma Scheffler-Mendoza, Sara Espinosa-Padilla, Andrew… Leer más »Coronavirus disease 2019 in patients with inborn errors of immunity: An international study.

Basiliximab impairs regulatory T cell (TREG) function and could affect the short-term graft acceptance in children with heart transplantation.

enero 12, 2021 DOI: 10.1038/s41598-020-80567-9

Jacobo López-Abente, Marta Martínez-Bonet, Esther Bernaldo-de-Quirós, Manuela Camino, Nuria Gil, Esther Panadero, Juan Miguel Gil-Jaurena, Maribel Clemente, Simon Urschel, Lori West, Marjorie Pion and Rafael Correa-Rocha. Sci Rep 2021 Jan 12;11(1):827. DOI: 10.1038/s41598-020-80567-9 Abstract CD25, the alpha chain of the IL-2 receptor, is expressed on activated effector T cells that mediate immune graft damage. Induction immunosuppression is commonly used in solid organ transplantation and can include antibodies… Leer más »Basiliximab impairs regulatory T cell (TREG) function and could affect the short-term graft acceptance in children with heart transplantation.

Pigmented Dermatofibrosarcoma Protuberans: Description of a pediatric case.

diciembre 3, 2019 DOI: 10.32641/rchped.v91i1.1303. 

L M Nieto-Benito, Beatriz Berenguer-Fröhner, Verónica Parra-Blanco, Minia Campos-Domínguez. Rev Chil Pediatr 2020 Feb;91(1):99-104. Epub 2019 Dec 3. DOI: 10.32641/rchped.v91i1.1303.  Abstract Introduction: Bednar tumor is a rare low-grade sarcoma considered the pigmented variant of dermatofibrosarco ma protuberans (DFSP). Objective: To describe the clinical and histopathological characteristics, treatment and evolution of this rare neoplasm. Clinical case: A 9-year old female presented with a… Leer más »Pigmented Dermatofibrosarcoma Protuberans: Description of a pediatric case.

Imbalance in T-Helper 17 Cells and Targeted Therapy in an Infant with SAM-like Syndrome.

noviembre 28, 2019 DOI: 10.1056/NEJMc1908531

Angela Hernández-Martín, Rebeca Kennedy-Batalla, Elvira Cañedo, Esther Bernaldo-de-Quirós, Begoña Carazo-Gallego, Angel Vera, Antonio Torrelo, Lucero Noguera-Morel, Rogelio González-Sarmiento, Marieke Bolling, Marta Martínez-Bonet, Marjorie Pion, Rafael Correa-Rocha. N Engl J Med  2019 Nov 28;381(22):2176-2178. DOI: 10.1056/NEJMc1908531 The SAM syndrome, which is characterized by severe dermatitis, multiple allergies, and metabolic wasting (Online Mendelian Inheritance in Man number, 615508), is a congenital skin disease caused by mutations in the genes encoding… Leer más »Imbalance in T-Helper 17 Cells and Targeted Therapy in an Infant with SAM-like Syndrome.