Producción Científica

The establishment of cow’s milk protein allergy in infants is related with a deficit of regulatory T cells (Treg) and vitamin D.

enero 18, 2017 DOI: 10.1038/pr.2017.12

Laura Perezabad, Jacobo López-Abente, Elena Alonso-Lebrero, Elena Seoane, Marjorie Pion, Rafael Correa-Rocha. Pediatr Res. 2017 May;81(5):722-730. Epub 2017 Jan 18. DOI: 10.1038/pr.2017.12 Abstract Background:  Cow’s milk protein allergy (CMPA) is the most common food allergy in infants. However, little is known about which specific immune mechanisms are related with the CMPA onset. The objective was to investigate which immune alterations constitute differential factors… Leer más »The establishment of cow’s milk protein allergy in infants is related with a deficit of regulatory T cells (Treg) and vitamin D.

Functional Mechanisms of Treg in the Context of HIV Infection and the Janus Face of Immune Suppression.

mayo 19, 2016 DOI: 10.3389/fimmu.2016.00192

Jacobo López-Abente, Rafael Correa-Rocha, Marjorie Pion. Front Immunol 2016 May 19;7:192. eCollection 2016. DOI: 10.3389/fimmu.2016.00192 Abstract Regulatory T cells (Tregs) play an important role in infections, by modulating host immune responses and avoiding the overreactive immunity that in the case of human immunodeficiency virus (HIV) infection leads to a marked erosion and deregulation of the entire immune system.… Leer más »Functional Mechanisms of Treg in the Context of HIV Infection and the Janus Face of Immune Suppression.

Nanotechnology as a New Therapeutic Approach to Prevent the HIV-Infection of Treg Cells.

enero 19, 2016 DOI: 10.1371/journal.pone.0145760

Didiana Jaramillo-Ruiz, Francisco Javier De La Mata, Rafael Gómez, Rafael Correa-Rocha, M Ángeles Muñoz-Fernández. PLoS One. 2016 Jan 19;11(1):e0145760. eCollection 2016. DOI: 10.1371/journal.pone.0145760 Abstract Background: HIV-1 has proved to infect regulatory T cells (Treg) modifying their phenotype and impairing their suppressive capacity. As Treg cells are a crucial component in the preservation of the immune homeostasis, we researched that the antiviral… Leer más »Nanotechnology as a New Therapeutic Approach to Prevent the HIV-Infection of Treg Cells.

HIV-1 induces B-cell activation and class switch recombination via spleen tyrosine kinase and c-Jun N-terminal kinase pathways.

octubre 23, 2014

Ana Judith Perisé-Barrios, Rafael Correa-Rocha, Susana Alvarez, Maria Angeles Muñoz-Fernandez, Marjorie Pion. AIDS 2014 Oct 23;28(16):2365-74. Abstract Objective:  Patients infected by the HIV type 1 (HIV-1) frequently show a general deregulation of immune system. A direct influence of HIV-1 particles on B-cell activation, proliferation and B-cell phenotype alterations has been recently described. Moreover, expression of activation-induced cytidinedeaminase (AID) mRNA,… Leer más »HIV-1 induces B-cell activation and class switch recombination via spleen tyrosine kinase and c-Jun N-terminal kinase pathways.

HIV-1 induces B-cell activation and class switch recombination via spleen tyrosine kinase and c-Jun N-terminal kinase pathways.

marzo 1, 2014 DOI: 10.1097/QAI.0000000000000092

Gema Méndez-Lagares, Didiana Jaramillo-Ruiz, Marjorie Pion, Manuel Leal, M A Muñoz-Fernández, Yolanda M Pacheco, Rafael Correa-Rocha. J Acquir Immune Defic Syndr . 2014 Mar 1;65(3):278-82. DOI: 10.1097/QAI.0000000000000092 Abstract Indexation of regulatory T cells (Treg) to the number of activated T cells constitutes a homeostatic mechanism ensuring that T-cell expansion remains under control. However, immune hyperactivation observed in HIV-infected patients suggests a possible dysfunction… Leer más »HIV-1 induces B-cell activation and class switch recombination via spleen tyrosine kinase and c-Jun N-terminal kinase pathways.

Low thymic output, peripheral homeostasis deregulation, and hastened regulatory T cells differentiation in children with 22q11.2 deletion syndrome.

enero 23, 2014

Sara Ferrando-Martínez, Raquel Lorente, Dolores Gurbindo, Ma Isabel De José, Manuel Leal, Ma Angeles Muñoz-Fernández, Rafael Correa-Rocha. J Pediatr. 2014 Apr;164(4).Epub 2014 Jan 23. Abstract Objective: To perform an extensive analysis of the immune status of asymptomatic children with the 22q11.2 deletion syndrome, with special emphasis on the regulatory T cells (Treg) population. Study design: Analysis of thymic function, frequency and absolute counts of… Leer más »Low thymic output, peripheral homeostasis deregulation, and hastened regulatory T cells differentiation in children with 22q11.2 deletion syndrome.

Induction of Treg cells after oral immunotherapy in hen’s egg-allergic children.

octubre 7, 2013 DOI: 10.1111/pai.12137

Victoria Fuentes-Aparicio, Elena Alonso-Lebrero, Lidia Zapatero, Sonsoles Infante, Raquel Lorente, M Ángeles Muñoz-Fernández, Rafael Correa-Rocha. Pediatr Allergy Immunol  2014 Feb;25(1):103-6. Epub 2013 Oct 7. DOI: 10.1111/pai.12137 Induction of Treg cells after oral immunotherapy in hen’s egg‐allergic children – Fuentes‐Aparicio – 2014 – Pediatric Allergy and Immunology – Wiley Online Library

HIV infection of human regulatory T cells downregulates Foxp3 expression by increasing DNMT3b levels and DNA methylation in the FOXP3 gene.

agosto 24, 2013 DOI: 10.1097/QAD.0b013e32836253fd

Marjorie Pion, Didiana Jaramillo-Ruiz, Alberto Martínez, M Angeles Muñoz-Fernández, Rafael Correa-Rocha. AIDS 2013 Aug 24;27(13):2019-29.  DOI: 10.1097/QAD.0b013e32836253fd Abstract Objective: Regulatory T cells (Tregs) play an important role in infections modulating host immune responses and avoiding overreactive immunity. The mechanisms underlying their action in HIV-infected patients have not been well established. HIV can infect Treg, but little is known about the effects… Leer más »HIV infection of human regulatory T cells downregulates Foxp3 expression by increasing DNMT3b levels and DNA methylation in the FOXP3 gene.

Oral immunotherapy in hen’s egg-allergic children increases a hypo-proliferative subset of CD4+ T cells that could constitute a marker of tolerance achievement.

julio 26, 2012 DOII: 10.1111/j.1399-3038.2012.01333.x

Victoria Fuentes-Aparicio, Elena Alonso-Lebrero, Lidia Zapatero, Sonsoles Infante, Raquel Lorente, Ma Ángeles Muñoz-Fernández, Rafael Correa-Rocha. Pediatr Allergy Immunol . 2012 Nov;23(7):648-53. Epub 2012 Jul 26. DOI: 10.1111/j.1399-3038.2012.01333.x Abstract Background: Food allergy affects a significant number of children and its prevalence, and persistence is undergoing an important increase in the last years. Specific oral tolerance induction (SOTI) is a promising… Leer más »Oral immunotherapy in hen’s egg-allergic children increases a hypo-proliferative subset of CD4+ T cells that could constitute a marker of tolerance achievement.