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Nanotechnology as a New Therapeutic Approach to Prevent the HIV-Infection of Treg Cells. imagen

Nanotechnology as a New Therapeutic Approach to Prevent the HIV-Infection of Treg Cells.

enero 19, 2016 DOI: 10.1371/journal.pone.0145760

Didiana Jaramillo-Ruiz, Francisco Javier De La Mata, Rafael Gómez, Rafael Correa-Rocha, M Ángeles Muñoz-Fernández. PLoS One. 2016 Jan 19;11(1):e0145760. eCollection 2016. DOI: 10.1371/journal.pone.0145760 Abstract Background: HIV-1 has proved to infect regulatory T cells (Treg) modifying their phenotype and impairing their suppressive capacity. As Treg cells are a crucial component in the preservation of the immune homeostasis, we researched that the antiviral… Leer más »Nanotechnology as a New Therapeutic Approach to Prevent the HIV-Infection of Treg Cells.

HIV-1 induces B-cell activation and class switch recombination via spleen tyrosine kinase and c-Jun N-terminal kinase pathways. imagen

HIV-1 induces B-cell activation and class switch recombination via spleen tyrosine kinase and c-Jun N-terminal kinase pathways.

octubre 23, 2014

Ana Judith Perisé-Barrios, Rafael Correa-Rocha, Susana Alvarez, Maria Angeles Muñoz-Fernandez, Marjorie Pion. AIDS 2014 Oct 23;28(16):2365-74. Abstract Objective:  Patients infected by the HIV type 1 (HIV-1) frequently show a general deregulation of immune system. A direct influence of HIV-1 particles on B-cell activation, proliferation and B-cell phenotype alterations has been recently described. Moreover, expression of activation-induced cytidinedeaminase (AID) mRNA,… Leer más »HIV-1 induces B-cell activation and class switch recombination via spleen tyrosine kinase and c-Jun N-terminal kinase pathways.

HIV-1 induces B-cell activation and class switch recombination via spleen tyrosine kinase and c-Jun N-terminal kinase pathways. imagen

HIV-1 induces B-cell activation and class switch recombination via spleen tyrosine kinase and c-Jun N-terminal kinase pathways.

marzo 1, 2014 DOI: 10.1097/QAI.0000000000000092

Gema Méndez-Lagares, Didiana Jaramillo-Ruiz, Marjorie Pion, Manuel Leal, M A Muñoz-Fernández, Yolanda M Pacheco, Rafael Correa-Rocha. J Acquir Immune Defic Syndr . 2014 Mar 1;65(3):278-82. DOI: 10.1097/QAI.0000000000000092 Abstract Indexation of regulatory T cells (Treg) to the number of activated T cells constitutes a homeostatic mechanism ensuring that T-cell expansion remains under control. However, immune hyperactivation observed in HIV-infected patients suggests a possible dysfunction… Leer más »HIV-1 induces B-cell activation and class switch recombination via spleen tyrosine kinase and c-Jun N-terminal kinase pathways.

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Low thymic output, peripheral homeostasis deregulation, and hastened regulatory T cells differentiation in children with 22q11.2 deletion syndrome.

enero 23, 2014

Sara Ferrando-Martínez, Raquel Lorente, Dolores Gurbindo, Ma Isabel De José, Manuel Leal, Ma Angeles Muñoz-Fernández, Rafael Correa-Rocha. J Pediatr. 2014 Apr;164(4).Epub 2014 Jan 23. Abstract Objective: To perform an extensive analysis of the immune status of asymptomatic children with the 22q11.2 deletion syndrome, with special emphasis on the regulatory T cells (Treg) population. Study design: Analysis of thymic function, frequency and absolute counts of… Leer más »Low thymic output, peripheral homeostasis deregulation, and hastened regulatory T cells differentiation in children with 22q11.2 deletion syndrome.

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Induction of Treg cells after oral immunotherapy in hen’s egg-allergic children.

octubre 7, 2013 DOI: 10.1111/pai.12137

Victoria Fuentes-Aparicio, Elena Alonso-Lebrero, Lidia Zapatero, Sonsoles Infante, Raquel Lorente, M Ángeles Muñoz-Fernández, Rafael Correa-Rocha. Pediatr Allergy Immunol  2014 Feb;25(1):103-6. Epub 2013 Oct 7. DOI: 10.1111/pai.12137 Induction of Treg cells after oral immunotherapy in hen’s egg‐allergic children – Fuentes‐Aparicio – 2014 – Pediatric Allergy and Immunology – Wiley Online Library

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HIV infection of human regulatory T cells downregulates Foxp3 expression by increasing DNMT3b levels and DNA methylation in the FOXP3 gene.

agosto 24, 2013 DOI: 10.1097/QAD.0b013e32836253fd

Marjorie Pion, Didiana Jaramillo-Ruiz, Alberto Martínez, M Angeles Muñoz-Fernández, Rafael Correa-Rocha. AIDS 2013 Aug 24;27(13):2019-29.  DOI: 10.1097/QAD.0b013e32836253fd Abstract Objective: Regulatory T cells (Tregs) play an important role in infections modulating host immune responses and avoiding overreactive immunity. The mechanisms underlying their action in HIV-infected patients have not been well established. HIV can infect Treg, but little is known about the effects… Leer más »HIV infection of human regulatory T cells downregulates Foxp3 expression by increasing DNMT3b levels and DNA methylation in the FOXP3 gene.

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Oral immunotherapy in hen’s egg-allergic children increases a hypo-proliferative subset of CD4+ T cells that could constitute a marker of tolerance achievement.

julio 26, 2012 DOII: 10.1111/j.1399-3038.2012.01333.x

Victoria Fuentes-Aparicio, Elena Alonso-Lebrero, Lidia Zapatero, Sonsoles Infante, Raquel Lorente, Ma Ángeles Muñoz-Fernández, Rafael Correa-Rocha. Pediatr Allergy Immunol . 2012 Nov;23(7):648-53. Epub 2012 Jul 26. DOI: 10.1111/j.1399-3038.2012.01333.x Abstract Background: Food allergy affects a significant number of children and its prevalence, and persistence is undergoing an important increase in the last years. Specific oral tolerance induction (SOTI) is a promising… Leer más »Oral immunotherapy in hen’s egg-allergic children increases a hypo-proliferative subset of CD4+ T cells that could constitute a marker of tolerance achievement.