Producción Científica

Pigmented Dermatofibrosarcoma Protuberans: Description of a pediatric case.

diciembre 3, 2019 DOI: 10.32641/rchped.v91i1.1303. 

L M Nieto-Benito, Beatriz Berenguer-Fröhner, Verónica Parra-Blanco, Minia Campos-Domínguez. Rev Chil Pediatr 2020 Feb;91(1):99-104. Epub 2019 Dec 3. DOI: 10.32641/rchped.v91i1.1303.  Abstract Introduction: Bednar tumor is a rare low-grade sarcoma considered the pigmented variant of dermatofibrosarco ma protuberans (DFSP). Objective: To describe the clinical and histopathological characteristics, treatment and evolution of this rare neoplasm. Clinical case: A 9-year old female presented with a… Leer más »Pigmented Dermatofibrosarcoma Protuberans: Description of a pediatric case.

Imbalance in T-Helper 17 Cells and Targeted Therapy in an Infant with SAM-like Syndrome.

noviembre 28, 2019 DOI: 10.1056/NEJMc1908531

Angela Hernández-Martín, Rebeca Kennedy-Batalla, Elvira Cañedo, Esther Bernaldo-de-Quirós, Begoña Carazo-Gallego, Angel Vera, Antonio Torrelo, Lucero Noguera-Morel, Rogelio González-Sarmiento, Marieke Bolling, Marta Martínez-Bonet, Marjorie Pion, Rafael Correa-Rocha. N Engl J Med  2019 Nov 28;381(22):2176-2178. DOI: 10.1056/NEJMc1908531 The SAM syndrome, which is characterized by severe dermatitis, multiple allergies, and metabolic wasting (Online Mendelian Inheritance in Man number, 615508), is a congenital skin disease caused by mutations in the genes encoding… Leer más »Imbalance in T-Helper 17 Cells and Targeted Therapy in an Infant with SAM-like Syndrome.

Analysis of the dysregulation between regulatory B and T cells (Breg and Treg) in human immunodeficiency virus (HIV)-infected patients.

marzo 27, 2019 DOI: 10.1371/journal.pone.0213744

Carolina Gutiérrez, Jacobo Lopez-Abente, Verónica Pérez-Fernández, Adrián Prieto-Sánchez, Rafael Correa-Rocha, Santiago Moreno-Guillen, María-Ángeles Muñoz-Fernández, Marjorie Pion. PLoS One 2019 Mar 27;14(3):e0213744. eCollection 2019. DOI: 10.1371/journal.pone.0213744 Abstract This study examines the relationship between regulatory B (Breg) and T (Treg) compartments, which play crucial roles in the maintenance of immune homeostasis in the context of HIV. Using flow cytometry, the phenotypes of different Breg and… Leer más »Analysis of the dysregulation between regulatory B and T cells (Breg and Treg) in human immunodeficiency virus (HIV)-infected patients.

Immune dysregulation and Th2 polarization are associated with atopic dermatitis in heart-transplant children: A delicate balance between risk of rejection or atopic symptoms.

enero 25, 2019 DOI: 10.1111/ajt.15245

Jacobo López-Abente, Esther Bernaldo-de-Quirós, Manuela Camino, Nuria Gil, Esther Panadero, Minia Campos-Domínguez, Elena Seoane-Reula, Juan M Gil-Jaurena, Marjorie Pion, Rafael Correa-Rocha. Am J Transplant 2019 May;19(5):1536-1544. Epub 2019 Jan 25. DOI: 10.1111/ajt.15245 Abstract Atopic dermatitis (AD) has a high incidence in heart-transplant children, and the reason why there is more AD after transplantation is still unknown. We conducted a cross-sectional study comparing 11 AD and… Leer más »Immune dysregulation and Th2 polarization are associated with atopic dermatitis in heart-transplant children: A delicate balance between risk of rejection or atopic symptoms.

Human immunodeficiency virus type-1 induces a regulatory B cell-like phenotype in vitro.

octubre 15, 2018 DOI: 10.1038/cmi.2017.48. 

Jacobo Lopez-Abente, Adrián Prieto-Sanchez, Maria-Ángeles Muñoz-Fernandez, Rafael Correa-Rocha, Marjorie Pion. Cell Mol Immunol. 2018 Oct;15(10):917-933. Epub 2017 Jul 17.  DOI: 10.1038/cmi.2017.48.  Abstract Individuals infected with human immunodeficiency virus type-1 (HIV-1) usually show a general dysregulation and hyper-activation of the immune system. A direct influence of HIV-1 particles on B-cell phenotypes and functions has been previously described. However, the consequences of… Leer más »Human immunodeficiency virus type-1 induces a regulatory B cell-like phenotype in vitro.

CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1+ viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion.

agosto 30, 2018 DOI: 10.1371/journal.pone.0203419. 

Rafael Correa-Rocha, Jacobo Lopez-Abente, Carolina Gutierrez, Verónica Astrid Pérez-Fernández, Adrián Prieto-Sánchez, Santiago Moreno-Guillen, María-Ángeles Muñoz-Fernández, Marjorie Pion. PLoS One 2018 Aug 30;13(8):e0203419. eCollection 2018. DOI: 10.1371/journal.pone.0203419.  Abstract In our work, we analyzed the role of the CD100/CD72 and PD-1/PD-L1 axes in immune response dysfunction in human immunodeficiency virus (HIV)-1 infection in which high expressions of PD-1 and PD-L1 were associated with an… Leer más »CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1+ viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion.

Th1/Th2 Imbalance and Early Age to Transplantation is Associated to Atopic Dermatitis in Heart-Transplanted Pediatric Patients.

julio 1, 2018 DOI: 10.1097/01.tp.0000542766.40479.8a

de Quiros Plaza, Esther Bernaldo; López-Abente, Jacobo; Camino, Manuela; Gil, Nuria; Panadero, Esther; Campos, Minia; Seoane, Elena; Pion, Marjorie; Correa-Rocha, Rafael. Transplantation: July 2018 – Volume 102 – Issue – p S143 DOI: 10.1097/01.tp.0000542766.40479.8a Abstract Introduction  Heart transplantation is a successful strategy for the treatment of end-stage pediatric heart diseases. In recent years, improved therapies and… Leer más »Th1/Th2 Imbalance and Early Age to Transplantation is Associated to Atopic Dermatitis in Heart-Transplanted Pediatric Patients.

“First-In-Human” Clinical Trial Employing Adoptive Transfer of Autologous Thymus-Derived Treg Cells (thyTreg) to Prevent Graft Rejection in Heart-Transplanted Children.

DOI: 10.1097/01.tp.0000542859.38902.af

Esther Bernaldo de Quirós, Manuela Camino, Nuria Gil, Esther Panadero, Constancio Medrano, Juan Miguel Gil-Jaurena, Marjorie Pion, Giovanna Lombardi, Megan K Levings, Lori J West, Rafael Correa-Rocha. Transplantation: July 2018 – Volume 102 – Issue – p S205 DOI: 10.1097/01.tp.0000542859.38902.af Abstract Immune allograft rejection remains the main obstacle to reach successful transplants. Transfer of regulatory T… Leer más »“First-In-Human” Clinical Trial Employing Adoptive Transfer of Autologous Thymus-Derived Treg Cells (thyTreg) to Prevent Graft Rejection in Heart-Transplanted Children.

Generation of Human Breg-Like Phenotype with Regulatory Function In Vitro with Bacteria-Derived Oligodeoxynucleotides.

junio 12, 2018 DOI: 10.3390/ijms19061737

Jorge Gallego-Valle, Verónica Astrid Pérez-Fernández, Rafael Correa-Rocha, Marjorie Pion. Int J Mol Sci 2018 Jun 12;19(6):1737. DOI: 10.3390/ijms19061737 Abstract Regulatory B cells (Bregs) participate in auto-tolerance maintenance and immune homeostasis. Despite their impact on many diseases and due to the difficulty to define them, knowledge about their origin and their physiological inducers is still unclear. The incomplete understanding about… Leer más »Generation of Human Breg-Like Phenotype with Regulatory Function In Vitro with Bacteria-Derived Oligodeoxynucleotides.

The role of regulatory T cells in the acquisition of tolerance to food allergens in children.

mayo 5, 2018 DOI: 10.1016/j.aller.2018.02.002

E Bernaldo de Quiros, E Seoane-Reula, E Alonso-Lebrero, M Pion, R Correa-Rocha. Allergol Immunopathol (Madr)Nov-Dec 2018;46(6):612-618. Epub 2018 May 5. DOI: 10.1016/j.aller.2018.02.002 Abstract Food allergy is a pathological immune reaction that identifies certain harmless food proteins, usually tolerated by the majority of the people, as a threat. The prevalence of these food allergies is increasing worldwide and currently affects 8%… Leer más »The role of regulatory T cells in the acquisition of tolerance to food allergens in children.