Producción Científica

Analysis of the dysregulation between regulatory B and T cells (Breg and Treg) in human immunodeficiency virus (HIV)-infected patients.

marzo 27, 2019 DOI: 10.1371/journal.pone.0213744

Carolina Gutiérrez, Jacobo Lopez-Abente, Verónica Pérez-Fernández, Adrián Prieto-Sánchez, Rafael Correa-Rocha, Santiago Moreno-Guillen, María-Ángeles Muñoz-Fernández, Marjorie Pion. PLoS One 2019 Mar 27;14(3):e0213744. eCollection 2019. DOI: 10.1371/journal.pone.0213744 Abstract This study examines the relationship between regulatory B (Breg) and T (Treg) compartments, which play crucial roles in the maintenance of immune homeostasis in the context of HIV. Using flow cytometry, the phenotypes of different Breg and… Leer más »Analysis of the dysregulation between regulatory B and T cells (Breg and Treg) in human immunodeficiency virus (HIV)-infected patients.

Immune dysregulation and Th2 polarization are associated with atopic dermatitis in heart-transplant children: A delicate balance between risk of rejection or atopic symptoms.

enero 25, 2019 DOI: 10.1111/ajt.15245

Jacobo López-Abente, Esther Bernaldo-de-Quirós, Manuela Camino, Nuria Gil, Esther Panadero, Minia Campos-Domínguez, Elena Seoane-Reula, Juan M Gil-Jaurena, Marjorie Pion, Rafael Correa-Rocha. Am J Transplant 2019 May;19(5):1536-1544. Epub 2019 Jan 25. DOI: 10.1111/ajt.15245 Abstract Atopic dermatitis (AD) has a high incidence in heart-transplant children, and the reason why there is more AD after transplantation is still unknown. We conducted a cross-sectional study comparing 11 AD and… Leer más »Immune dysregulation and Th2 polarization are associated with atopic dermatitis in heart-transplant children: A delicate balance between risk of rejection or atopic symptoms.

Human immunodeficiency virus type-1 induces a regulatory B cell-like phenotype in vitro.

octubre 15, 2018 DOI: 10.1038/cmi.2017.48. 

Jacobo Lopez-Abente, Adrián Prieto-Sanchez, Maria-Ángeles Muñoz-Fernandez, Rafael Correa-Rocha, Marjorie Pion. Cell Mol Immunol. 2018 Oct;15(10):917-933. Epub 2017 Jul 17.  DOI: 10.1038/cmi.2017.48.  Abstract Individuals infected with human immunodeficiency virus type-1 (HIV-1) usually show a general dysregulation and hyper-activation of the immune system. A direct influence of HIV-1 particles on B-cell phenotypes and functions has been previously described. However, the consequences of… Leer más »Human immunodeficiency virus type-1 induces a regulatory B cell-like phenotype in vitro.

CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1+ viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion.

agosto 30, 2018 DOI: 10.1371/journal.pone.0203419. 

Rafael Correa-Rocha, Jacobo Lopez-Abente, Carolina Gutierrez, Verónica Astrid Pérez-Fernández, Adrián Prieto-Sánchez, Santiago Moreno-Guillen, María-Ángeles Muñoz-Fernández, Marjorie Pion. PLoS One 2018 Aug 30;13(8):e0203419. eCollection 2018. DOI: 10.1371/journal.pone.0203419.  Abstract In our work, we analyzed the role of the CD100/CD72 and PD-1/PD-L1 axes in immune response dysfunction in human immunodeficiency virus (HIV)-1 infection in which high expressions of PD-1 and PD-L1 were associated with an… Leer más »CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1+ viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion.

Th1/Th2 Imbalance and Early Age to Transplantation is Associated to Atopic Dermatitis in Heart-Transplanted Pediatric Patients.

julio 1, 2018 DOI: 10.1097/01.tp.0000542766.40479.8a

de Quiros Plaza, Esther Bernaldo; López-Abente, Jacobo; Camino, Manuela; Gil, Nuria; Panadero, Esther; Campos, Minia; Seoane, Elena; Pion, Marjorie; Correa-Rocha, Rafael. Transplantation: July 2018 – Volume 102 – Issue – p S143 DOI: 10.1097/01.tp.0000542766.40479.8a Abstract Introduction  Heart transplantation is a successful strategy for the treatment of end-stage pediatric heart diseases. In recent years, improved therapies and… Leer más »Th1/Th2 Imbalance and Early Age to Transplantation is Associated to Atopic Dermatitis in Heart-Transplanted Pediatric Patients.

“First-In-Human” Clinical Trial Employing Adoptive Transfer of Autologous Thymus-Derived Treg Cells (thyTreg) to Prevent Graft Rejection in Heart-Transplanted Children.

DOI: 10.1097/01.tp.0000542859.38902.af

Esther Bernaldo de Quirós, Manuela Camino, Nuria Gil, Esther Panadero, Constancio Medrano, Juan Miguel Gil-Jaurena, Marjorie Pion, Giovanna Lombardi, Megan K Levings, Lori J West, Rafael Correa-Rocha. Transplantation: July 2018 – Volume 102 – Issue – p S205 DOI: 10.1097/01.tp.0000542859.38902.af Abstract Immune allograft rejection remains the main obstacle to reach successful transplants. Transfer of regulatory T… Leer más »“First-In-Human” Clinical Trial Employing Adoptive Transfer of Autologous Thymus-Derived Treg Cells (thyTreg) to Prevent Graft Rejection in Heart-Transplanted Children.

Generation of Human Breg-Like Phenotype with Regulatory Function In Vitro with Bacteria-Derived Oligodeoxynucleotides.

junio 12, 2018 DOI: 10.3390/ijms19061737

Jorge Gallego-Valle, Verónica Astrid Pérez-Fernández, Rafael Correa-Rocha, Marjorie Pion. Int J Mol Sci 2018 Jun 12;19(6):1737. DOI: 10.3390/ijms19061737 Abstract Regulatory B cells (Bregs) participate in auto-tolerance maintenance and immune homeostasis. Despite their impact on many diseases and due to the difficulty to define them, knowledge about their origin and their physiological inducers is still unclear. The incomplete understanding about… Leer más »Generation of Human Breg-Like Phenotype with Regulatory Function In Vitro with Bacteria-Derived Oligodeoxynucleotides.

The role of regulatory T cells in the acquisition of tolerance to food allergens in children.

mayo 5, 2018 DOI: 10.1016/j.aller.2018.02.002

E Bernaldo de Quiros, E Seoane-Reula, E Alonso-Lebrero, M Pion, R Correa-Rocha. Allergol Immunopathol (Madr)Nov-Dec 2018;46(6):612-618. Epub 2018 May 5. DOI: 10.1016/j.aller.2018.02.002 Abstract Food allergy is a pathological immune reaction that identifies certain harmless food proteins, usually tolerated by the majority of the people, as a threat. The prevalence of these food allergies is increasing worldwide and currently affects 8%… Leer más »The role of regulatory T cells in the acquisition of tolerance to food allergens in children.

The establishment of cow’s milk protein allergy in infants is related with a deficit of regulatory T cells (Treg) and vitamin D.

enero 18, 2017 DOI: 10.1038/pr.2017.12

Laura Perezabad, Jacobo López-Abente, Elena Alonso-Lebrero, Elena Seoane, Marjorie Pion, Rafael Correa-Rocha. Pediatr Res. 2017 May;81(5):722-730. Epub 2017 Jan 18. DOI: 10.1038/pr.2017.12 Abstract Background:  Cow’s milk protein allergy (CMPA) is the most common food allergy in infants. However, little is known about which specific immune mechanisms are related with the CMPA onset. The objective was to investigate which immune alterations constitute differential factors… Leer más »The establishment of cow’s milk protein allergy in infants is related with a deficit of regulatory T cells (Treg) and vitamin D.

Functional Mechanisms of Treg in the Context of HIV Infection and the Janus Face of Immune Suppression.

mayo 19, 2016 DOI: 10.3389/fimmu.2016.00192

Jacobo López-Abente, Rafael Correa-Rocha, Marjorie Pion. Front Immunol 2016 May 19;7:192. eCollection 2016. DOI: 10.3389/fimmu.2016.00192 Abstract Regulatory T cells (Tregs) play an important role in infections, by modulating host immune responses and avoiding the overreactive immunity that in the case of human immunodeficiency virus (HIV) infection leads to a marked erosion and deregulation of the entire immune system.… Leer más »Functional Mechanisms of Treg in the Context of HIV Infection and the Janus Face of Immune Suppression.