Saltar al contenido
Portada » News » CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1+ viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion.

CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1+ viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion.

Rafael Correa-Rocha, Jacobo Lopez-Abente, Carolina Gutierrez, Verónica Astrid Pérez-Fernández, Adrián Prieto-Sánchez, Santiago Moreno-Guillen, María-Ángeles Muñoz-Fernández, Marjorie Pion.

PLoS One 2018 Aug 30;13(8):e0203419. eCollection 2018.

DOI: 10.1371/journal.pone.0203419. 

Abstract

In our work, we analyzed the role of the CD100/CD72 and PD-1/PD-L1 axes in immune response dysfunction in human immunodeficiency virus (HIV)-1 infection in which high expressions of PD-1 and PD-L1 were associated with an immunosuppressive state via limitation of the HIV-1-specific T-cell responses.

CD100 was demonstrated to play a relevant role in immune responses in various pathological processes and may be responsible for immune dysregulation during HIV-1 infection.

We investigated the function of CD72/CD100, and PD-1/PDL-1 axes on T and B cells in HIV-infected individuals and in healthy individuals.

We analyzed the frequencies and fluorescence intensities of these four markers on CD4+, CD8+ T and B cells.

Marker expressions were increased during active HIV-1 infection.

CD100 frequency on T cells was positively associated with the expression of PD-1 and PD-L1 on T cells from HIV-infected treatment-naïve individuals.

In addition, the frequency of CD72-expressing T cells was associated with interferon gamma (IFN-γ) production in HIV-infected treatment-naïve individuals.

Our data suggest that the CD72/CD100 and PD-1/PD-L1 axes may jointly participate in dysregulation of immunity during HIV-1 infection and could partially explain the immune systems’ hyper-activation and exhaustion.

https://pubmed.ncbi.nlm.nih.gov/30161254/

Deja una respuesta

Tu dirección de correo electrónico no será publicada. Los campos obligatorios están marcados con *