de Quiros Plaza, Esther Bernaldo; López-Abente, Jacobo; Camino, Manuela; Gil, Nuria; Panadero, Esther; Campos, Minia; Seoane, Elena; Pion, Marjorie; Correa-Rocha, Rafael.
Transplantation: July 2018 – Volume 102 – Issue – p S143
Heart transplantation is a successful strategy for the treatment of end-stage pediatric heart diseases.
In recent years, improved therapies and clinical practice have led to increased graft survival, and consequently, chronic complications secondary to organ transplantation due in part to long-term immunosuppression have also emerged.
Allergies and atopic diseases, such as atopic dermatitis (AD) are among these chronic complications.
Despite that AD constitutes a frequent comorbidity in pediatric heart transplantation, little is known about the immune dysregulation underlying AD.
Therefore, our objective was to unravel the immune mechanisms leading to AD in order to improve the clinical management of this disease in heart-transplanted children.
The early age at transplantation and the use of immunosuppressors are critical factors that could disturb the immune homeostasis in a period that is crucial for the correct maturation of the immune system.
This immune dysregulation could produce an imbalance in the Th1/Th2 immune responses, predisposing transplanted infants to AD.
As a potential mechanism of this fact, the immune dysregulation may result in an impairment of Treg capacity to control IL-4-secreting CD4+ T cell expansion, which could lead to an activation of the Th2 responses in AD heart-transplanted infants.
Th1/Th2 Imbalance and Early Age to Transplantation is Associ… : Transplantation (lww.com)