Saltar al contenido
Portada » News » HIV-1 induces B-cell activation and class switch recombination via spleen tyrosine kinase and c-Jun N-terminal kinase pathways.

HIV-1 induces B-cell activation and class switch recombination via spleen tyrosine kinase and c-Jun N-terminal kinase pathways.

Gema Méndez-Lagares, Didiana Jaramillo-Ruiz, Marjorie Pion, Manuel Leal, M A Muñoz-Fernández, Yolanda M Pacheco, Rafael Correa-Rocha.

J Acquir Immune Defic Syndr . 2014 Mar 1;65(3):278-82.

DOI: 10.1097/QAI.0000000000000092

Abstract

Indexation of regulatory T cells (Treg) to the number of activated T cells constitutes a homeostatic mechanism ensuring that T-cell expansion remains under control.

However, immune hyperactivation observed in HIV-infected patients suggests a possible dysfunction of this mechanism.

Here we show that the Treg/IL-2-producing cells’ balance is deeply disturbed in viremic HIV-infected patients.

We found a lower expression of IL-2 receptor alpha on Treg from viremic patients.

We confirmed in vitro that HIV infection of Treg downregulates IL-2 receptor alpha and phosphorylated STAT5.

Our results argue for an impaired capacity of Treg to sense the expansion of activated T cells in HIV-infected patients that could contribute to the immune deregulation.

HIV infection deregulates the balance between regulatory T cells and IL-2-producing CD4 T cells by decreasing the expression of the IL-2 receptor in Treg – PubMed (nih.gov)

Deja una respuesta

Tu dirección de correo electrónico no será publicada. Los campos obligatorios están marcados con *