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Portada » News » Reciente publicación 14 octubre 2021 sobre «Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73».

Reciente publicación 14 octubre 2021 sobre «Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73».

Lorna B Jarvis, Daniel B Rainbow, Valerie Coppard, Sarah K Howlett, Zoya Georgieva, Jessica L Davies, Harpreet Kaur Mullay, Joanna Hester, Tom Ashmore, Aletta Van Den Bosch, James T Grist, Alasdair J Coles, Hani S Mousa, Stefano Pluchino, Krishnaa T Mahbubani, Julian L Griffin, Kourosh Saeb-Parsy, Fadi Issa, Luca Peruzzotti-Jametti, Linda S Wicker, Joanne L Jones.

Commun Biol  2021 Oct 14;4(1):1186.

DOI: 10.1038/s42003-021-02721-x

Abstract

The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity.

However, because large cell numbers are needed to achieve a therapeutic effect, in vitro expansion is required.

By comparing their function, phenotype and transcriptomic profile against ex vivo Tregs, we demonstrate that expanded human Tregs switch their metabolism to aerobic glycolysis and show enhanced suppressive function through hypoxia-inducible factor 1-alpha (HIF1A) driven acquisition of CD73 expression.

In conjunction with CD39, CD73 expression enables expanded Tregs to convert ATP to immunosuppressive adenosine.

We conclude that for maximum therapeutic benefit, Treg expansion protocols should be optimised for CD39/CD73 co-expression.

Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73 – PubMed (nih.gov)

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