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IL-1β-driven osteoclastogenic Tregs accelerate bone erosion in arthritis.

Anaïs Levescot, Margaret H Chang, Julia Schnell, Nathan Nelson-Maney, Jing Yan, Marta Martínez-Bonet, Ricardo Grieshaber-Bouyer, Pui Y Lee, Kevin Wei, Rachel B Blaustein, Allyn Morris, Alexandra Wactor, Yoichiro Iwakura, James A Lederer, Deepak A Rao, Julia F Charles, Peter A Nigrovic. J Clin Invest. 2021 Sep 15;131(18):e141008. DOI: 10.1172/JCI141008 Abstract IL-1β is a proinflammatory mediator with roles in innate and adaptive immunity. Here we show that IL-1β contributes to autoimmune arthritis by inducing osteoclastogenic capacity in Tregs. Using mice with joint inflammation arising through deficiency of the IL-1 receptor antagonist (Il1rn-/-), we observed that IL-1β blockade attenuated disease more effectively in early arthritis than in established arthritis, especially with respect to bone erosion. Protection was accompanied by a… Leer más »IL-1β-driven osteoclastogenic Tregs accelerate bone erosion in arthritis.

Interesante artículo sobre – Driving CARs to BARs: The Winding Road to Specific Regulatory T Cells for Tolerance.

David W. Scott – Department of Medicine (MED), Uniformed Services University of the Health Sciences, Bethesda, MD, United States. Front. Immunol., 06 September 2021 | https://doi.org/10.3389/fimmu.2021.742719 Chimeric antigen receptor (CAR) transduced T cells have significantly improved cancer immunotherapy. Similarly, engineering regulatory T cells (Treg) with specific receptors to endow specificity and increase efficacy of Tregs holds great promise for therapy of a variety of adverse immune responses. In this review, we focus on our approaches using retroviral transduction of specific T-cell receptors, single chain variable fragments (scFv) or antigen in models of monogenic diseases, autoimmunity and allergy. The advantages of each… Leer más »Interesante artículo sobre – Driving CARs to BARs: The Winding Road to Specific Regulatory T Cells for Tolerance.

Premian una investigación del Grupo LIR del Hospital Gregorio Marañón sobre células del tejido tímico.

La Sociedad de Inmunología de la Comunidad de Madrid ha premiado una investigación del Hospital Gregorio Marañón que busca la posibilidad de modificar genéticamente las células del tejido tímico para emplearlas en el tratamiento de patologías autoinmunes o rechazo de trasplantes. Se pretende encontrar otra fuente alternativa para la consecución de linfocitos T reguladores (Treg), que son de enorme importancia debido a su gran potencial terapéutico en el tratamiento de procesos inflamatorios. El Laboratorio de Inmuno-Regulación (LIR) del Hospital Gregorio Marañón ha sido premiado en el 42º Congreso de la Sociedad Española de Inmunología (SEI) por el trabajo titulado “Caracterización… Leer más »Premian una investigación del Grupo LIR del Hospital Gregorio Marañón sobre células del tejido tímico.

Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity.

Daniel Lozano-Ojalvo, Carmen Camara  Eduardo Lopez-Granados, Pilar Nozal, Lucía Del Pino-Molina, Luz Yadira Bravo-Gallego, Estela Paz-Artal , Marjorie Pion , Rafael Correa-Rocha , Alberto Ortiz, Marcos Lopez-Hoyos, Marta Erro Iribarren, Jose Portoles, Maria Pilar Rojo-Portoles, Gloria Ojeda, Isabel Cervera, Maria Gonzalez-Perez, Irene Bodega-Mayor, Maria Montes-Casado, Pilar Portoles, Mayte Perez-Olmeda, Jesus Oteo, Rodrigo Sanchez-Tarjuelo, Venu Pothula, Megan Schwarz, Manisha Brahmachary, Anthony Tanoto Tan, Nina Le Bert, Cecilia Berin, Antonio Bertoletti, Ernesto Guccione, Jordi Ochando. Cell Reports 36, 109570 August 24, 2021 DOI: 10.1016/j.celrep.2021.109570 ABSTRACT The rapid development of mRNA-based vaccines against the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) led to the design of accelerated vaccination schedules that have been extremely effective in naive individuals. While a two-dose immunization regimen with the BNT162b2 vaccine has been demonstrated to provide a 95% efficacy in naive individuals, the effects… Leer más »Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity.

Tratamiento pionero contra el rechazo de los órganos trasplantados.

Los investigadores del Laboratorio de Inmuno–regulación del Hospital Gregorio Marañón, responsables de este tratamiento pionero basado en terapia celular, han presentado hoy el resultado de su investigación, de más de seis años de duración, bajo la dirección de Rafael Correa y Co- Dirección de Marjorie Pion. Con esta nueva técnica con células Treg de tejido tímico (thyTreg) se pretende evitar el rechazo del órgano y llegar a la eliminación del uso de fármacos inmunodepresores. Al emplear las propias células del paciente, los efectos secundarios son mínimos, lo que también mejora la calidad de vida de la persona trasplantada. Esta terapia… Leer más »Tratamiento pionero contra el rechazo de los órganos trasplantados.

The Presence of a Marked Imbalance Between Regulatory T Cells and Effector T Cells Reveals That Tolerance Mechanisms Could Be Compromised in Heart Transplant Children.

Esther Bernaldo-de-Quirós, Jacobo López-Abente, Manuela Camino Nuria Gil, Esther Panadero, Rocío López-Esteban, Marta Martínez-Bonet, Marjorie Pion, Rafael Correa-Rocha. Transplant Direct. 2021 2021 Apr 23;7(5):e693 DOI: 10.1097/TXD.0000000000001152 Abstract Regulatory T cells (Treg) are crucial for the induction and maintenance of graft tolerance. In pediatric heart transplant procedures, the thymus is routinely excised, removing the primary source of T-cell replenishment. Consequently, thymectomy joined to the effects of immunosuppression on the T-cell compartment may have a detrimental impact on Treg values, compromising the intrinsic tolerance mechanisms and the protective role of Treg preventing graft rejection in heart transplant children. Methods: A prospective study including 7 heart transplant children was performed, and immune cell… Leer más »The Presence of a Marked Imbalance Between Regulatory T Cells and Effector T Cells Reveals That Tolerance Mechanisms Could Be Compromised in Heart Transplant Children.

Ectopic FOXP3 Expression in Combination with TGF-β1 and IL-2 Stimulation Generates Limited Suppressive Function in Human Primary Activated Thymocytes Ex Vivo.

Jorge Gallego-Valle, Sergio Gil-Manso, Ana Pita, Esther Bernaldo-de-Quirós, Rocío López-Esteban, Marta Martínez-Bonet, Verónica Astrid Pérez-Fernández, Ramón Pérez-Caballero, Carlos Pardo, Juan-Miguel Gil-Jaurena, Rafael Correa-Rocha and Marjorie Pion. Biomedicines 2021, 9(5), 461 DOI: 10.3390/biomedicines9050461 Abstract Regulatory T cells (Tregs), which are characterized by the expression of the transcription factor forkhead box P3 (FOXP3), are the main immune cells that induce tolerance and are regulators of immune homeostasis. Natural Treg cells (nTregs), described as CD4+CD25+FOXP3+, are generated in the thymus via activation and cytokine signaling. Transforming growth factor beta type 1 (TGF-β1) is pivotal to the generation of the nTreg lineage, its maintenance in the thymus,… Leer más »Ectopic FOXP3 Expression in Combination with TGF-β1 and IL-2 Stimulation Generates Limited Suppressive Function in Human Primary Activated Thymocytes Ex Vivo.

Colchicine treatment in children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome: A multicenter study in Spain.

Cristian Quintana-Ortega, Elena Seoane-Reula, Laura Fernández, Marisol Camacho, Peter Olbrich, Olaf Neth, Sara Murias, Clara Udaondo, Agustín Remesal, Cristina Calvo, Rosa Alcobendas. Eur J Rheumatol 2021; 8(2): 73-8 DOI: 10.5152/eurjrheum.2020.20102 Abstract Objective: To evaluate the efficacy of colchicine therapy in pediatric patients with PFAPA syndrome who present with an incomplete response to the standard treatment or with frequent episodes (an interval of less than 14 days between two disease flares). Methods: A multicenter cohort study of children diagnosed with PFAPA syndrome and treated with colchicine was performed in three separate hospitals located in Spain. The patients clinical and laboratory data were reviewed… Leer más »Colchicine treatment in children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome: A multicenter study in Spain.

Interesante artículo “Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When?”

See this image and copyright information in PMC Helen L Stark, Hayson C Wang, Jasmina Kuburic, Alaa Alzhrani, Joanna Hester, Fadi Issa. Front Immunol. 2021 Mar 25;12:664244.  DOI: 10.3389/fimmu.2021.664244 Abstract A number of immune regulatory cellular therapies, including regulatory T cells and mesenchymal stromal cells, have emerged as novel alternative therapies for the control of transplant alloresponses. Clinical studies have demonstrated their feasibility and safety, however developing our understanding of the impact of cellular therapeutics in vivo requires advanced immune monitoring strategies. To accurately monitor the immune response, a combination of complementary methods is required to measure the cellular and molecular phenotype as well as the function of cells… Leer más »Interesante artículo “Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When?”