Reciente publicación 14 octubre 2021 sobre “Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73”.
Lorna B Jarvis, Daniel B Rainbow, Valerie Coppard, Sarah K Howlett, Zoya Georgieva, Jessica L Davies, Harpreet Kaur Mullay, Joanna Hester, Tom Ashmore, Aletta Van Den Bosch, James T Grist, Alasdair J Coles, Hani S Mousa, Stefano Pluchino, Krishnaa T Mahbubani, Julian L Griffin, Kourosh Saeb-Parsy, Fadi Issa, Luca Peruzzotti-Jametti, Linda S Wicker, Joanne L Jones. Commun Biol 2021 Oct 14;4(1):1186. DOI: 10.1038/s42003-021-02721-x Abstract The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. However, because large cell numbers are needed to achieve a therapeutic effect, in vitro expansion is required. By comparing their function, phenotype and transcriptomic profile against ex vivo Tregs, we demonstrate that expanded human Tregs switch their metabolism to aerobic… Leer más »Reciente publicación 14 octubre 2021 sobre “Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73”.