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Beatriz Rodriguez

The Presence of a Marked Imbalance Between Regulatory T Cells and Effector T Cells Reveals That Tolerance Mechanisms Could Be Compromised in Heart Transplant Children.

Esther Bernaldo-de-Quirós, Jacobo López-Abente, Manuela Camino Nuria Gil, Esther Panadero, Rocío López-Esteban, Marta Martínez-Bonet, Marjorie Pion, Rafael Correa-Rocha. Transplant Direct. 2021 2021 Apr 23;7(5):e693 DOI: 10.1097/TXD.0000000000001152 Abstract Regulatory T cells (Treg) are crucial for the induction and maintenance of graft tolerance. In pediatric heart transplant procedures, the thymus is routinely excised, removing the primary source of T-cell replenishment. Consequently, thymectomy joined to the effects of immunosuppression on the T-cell compartment may have a detrimental impact on Treg values, compromising the intrinsic tolerance mechanisms and the protective role of Treg preventing graft rejection in heart transplant children. Methods: A prospective study including 7 heart transplant children was performed, and immune cell… Leer más »The Presence of a Marked Imbalance Between Regulatory T Cells and Effector T Cells Reveals That Tolerance Mechanisms Could Be Compromised in Heart Transplant Children.

Ectopic FOXP3 Expression in Combination with TGF-β1 and IL-2 Stimulation Generates Limited Suppressive Function in Human Primary Activated Thymocytes Ex Vivo.

Jorge Gallego-Valle, Sergio Gil-Manso, Ana Pita, Esther Bernaldo-de-Quirós, Rocío López-Esteban, Marta Martínez-Bonet, Verónica Astrid Pérez-Fernández, Ramón Pérez-Caballero, Carlos Pardo, Juan-Miguel Gil-Jaurena, Rafael Correa-Rocha and Marjorie Pion. Biomedicines 2021, 9(5), 461 DOI: 10.3390/biomedicines9050461 Abstract Regulatory T cells (Tregs), which are characterized by the expression of the transcription factor forkhead box P3 (FOXP3), are the main immune cells that induce tolerance and are regulators of immune homeostasis. Natural Treg cells (nTregs), described as CD4+CD25+FOXP3+, are generated in the thymus via activation and cytokine signaling. Transforming growth factor beta type 1 (TGF-β1) is pivotal to the generation of the nTreg lineage, its maintenance in the thymus,… Leer más »Ectopic FOXP3 Expression in Combination with TGF-β1 and IL-2 Stimulation Generates Limited Suppressive Function in Human Primary Activated Thymocytes Ex Vivo.

Colchicine treatment in children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome: A multicenter study in Spain.

Cristian Quintana-Ortega, Elena Seoane-Reula, Laura Fernández, Marisol Camacho, Peter Olbrich, Olaf Neth, Sara Murias, Clara Udaondo, Agustín Remesal, Cristina Calvo, Rosa Alcobendas. Eur J Rheumatol 2021; 8(2): 73-8 DOI: 10.5152/eurjrheum.2020.20102 Abstract Objective: To evaluate the efficacy of colchicine therapy in pediatric patients with PFAPA syndrome who present with an incomplete response to the standard treatment or with frequent episodes (an interval of less than 14 days between two disease flares). Methods: A multicenter cohort study of children diagnosed with PFAPA syndrome and treated with colchicine was performed in three separate hospitals located in Spain. The patients clinical and laboratory data were reviewed… Leer más »Colchicine treatment in children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome: A multicenter study in Spain.

Interesante artículo “Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When?”

See this image and copyright information in PMC Helen L Stark, Hayson C Wang, Jasmina Kuburic, Alaa Alzhrani, Joanna Hester, Fadi Issa. Front Immunol. 2021 Mar 25;12:664244.  DOI: 10.3389/fimmu.2021.664244 Abstract A number of immune regulatory cellular therapies, including regulatory T cells and mesenchymal stromal cells, have emerged as novel alternative therapies for the control of transplant alloresponses. Clinical studies have demonstrated their feasibility and safety, however developing our understanding of the impact of cellular therapeutics in vivo requires advanced immune monitoring strategies. To accurately monitor the immune response, a combination of complementary methods is required to measure the cellular and molecular phenotype as well as the function of cells… Leer más »Interesante artículo “Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When?”

Comunicación Oral – Congreso SEI 2021.

Sergio Gil Manso, Jorge Gallego Valle, Esther Bernaldo de Quiros, Rocio Lopez Esteban, Juan Miguel Gil Jaurena, Ana Pita, Rafael Correa Rocha, Marjorie Pion. CARACTERIZACIÓN Y FUNCIONALIDAD DE TIMOCITOS HUMANOS MODIFICADOS GENÉTICAMENTE PARA EXPRESAR FOXP3 MEDIANTE LENTIVECTORES. Las enfermedades autoinmunes y el rechazo de trasplantes son patologías asociadas a una desregulación o respuesta indeseada del sistema inmune frente a antígenos propios o del órgano trasplantado. Las células T reguladoras (Treg), caracterizadas por la expresión del factor de transcripción FOXP3, constituyen el principal mecanismo de tolerancia periférica y son células encargadas de normalizar esta desregulación y recuperar la homeostasis inmune gracias… Leer más »Comunicación Oral – Congreso SEI 2021.

Clinical course of severe patients with COVID-19 treated with tocilizumab: report from a cohort study in Spain.

Esther Chamorro-de-Vega, Carmen-Guadalupe Rodriguez-Gonzalez, Silvia Manrique-Rodríguez, Elena Lobato-Matilla, Felix García-Moreno, Maria Olmedo, Rafael Correa-Rocha, Maricela Valerio, Teresa Aldámiz-Echevarria, Marina Machado, Milagros Sancho-Gonzalez, Juan Carlos Lopez-Bernaldo-de-Quirós, Paula Ruiz-Briones, Rosa Romero-Jiménez, Camino Sarobe-González, Alvaro Gimenez-Manzorro, Roberto Collado-Borrell, Cecilia M Fernandez-Llamazares, Jose Luis Revuelta-Herrero, Beatriz Somoza-Fernandez, Sebastian Garcia-Sanchez, Irene Taladriz-Sender, Emilio Bouza, Ana Herranz, Patricia Muñoz &Maria Sanjurjo. Expert Review of Clinical Pharmacology – Volume 14, 2021 DOI:10.1080/17512433.2021.1875819 Abstract Background: We report the long-term outcomes, changes in laboratory parameters, the incidence of secondary nosocomial infections and treatment cost of a Spanish cohort of patients with severe COVID-19 that received tocilizumab (TCZ). Methods: Retrospective cohort… Leer más »Clinical course of severe patients with COVID-19 treated with tocilizumab: report from a cohort study in Spain.

Coronavirus disease 2019 in patients with inborn errors of immunity: An international study.

Isabelle Meyts, Giorgia Bucciol, Isabella Quinti, Bénédicte Neven, Alain Fischer, Elena Seoane, Eduardo Lopez-Granados, Carla Gianelli, Angel Robles-Marhuenda, Pierre-Yves Jeandel, Catherine Paillard, Vijay G Sankaran, Yesim Yilmaz Demirdag, Vassilios Lougaris, Alessandro Aiuti, Alessandro Plebani, Cinzia Milito, Virgil Ash Dalm, Kissy Guevara-Hoyer, Silvia Sánchez-Ramón, Liliana Bezrodnik, Federica Barzaghi, Luis Ignacio Gonzalez-Granado, Grant R Hayman, Gulbu Uzel, Leonardo Oliveira Mendonça, Carlo Agostini, Giuseppe Spadaro, Raffaele Badolato, Annarosa Soresina, François Vermeulen, Cedric Bosteels, Bart N Lambrecht, Michael Keller, Peter J Mustillo, Roshini S Abraham, Sudhir Gupta, Ahmet Ozen, Elif Karakoc-Aydiner, Safa Baris, Alexandra F Freeman, Marco Yamazaki-Nakashimada, Selma Scheffler-Mendoza, Sara Espinosa-Padilla, Andrew R Gennery, Stephen Jolles, Yazmin Espinosa, M Cecilia Poli, Claire Fieschi, Fabian Hauck, Charlotte Cunningham-Rundles, Nizar Mahlaoui, IKlaus Warnatz, Kathleen E Sullivan, Stuart G Tangye. J Allergy Clin Immunol 2021 Feb;147(2):520-531. DOI: 10.1016/j.jaci.2020.09.010 Abstract Background: There is uncertainty about the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in individuals with rare inborn errors… Leer más »Coronavirus disease 2019 in patients with inborn errors of immunity: An international study.

Basiliximab impairs regulatory T cell (TREG) function and could affect the short-term graft acceptance in children with heart transplantation.

Jacobo López-Abente, Marta Martínez-Bonet, Esther Bernaldo-de-Quirós, Manuela Camino, Nuria Gil, Esther Panadero, Juan Miguel Gil-Jaurena, Maribel Clemente, Simon Urschel, Lori West, Marjorie Pion and Rafael Correa-Rocha. Sci Rep 2021 Jan 12;11(1):827. DOI: 10.1038/s41598-020-80567-9 Abstract CD25, the alpha chain of the IL-2 receptor, is expressed on activated effector T cells that mediate immune graft damage. Induction immunosuppression is commonly used in solid organ transplantation and can include antibodies blocking CD25. However, regulatory T cells (Tregs) also rely on CD25 for their proliferation, survival, and regulatory function. Therefore, CD25-blockade may compromise Treg protective role against rejection. We analysed in vitro the effect of basiliximab (BXM) on the viability, phenotype, proliferation and cytokine production of… Leer más »Basiliximab impairs regulatory T cell (TREG) function and could affect the short-term graft acceptance in children with heart transplantation.

Cilastatin: a potential treatment strategy against COVID-19.

María Ángeles González-Nicolás, Cristian González-Guerrero, Verónica Astrid Pérez-Fernández, Alberto Lázaro. Clinical Kidney Journal, Volume 13, Issue 5, October 2020, Pages 903–905. DOI: 10.1093/ckj/sfaa193 Based on the preclinical evidence of kidney and lung protection in the context of endotoxemia as presented in this letter. We propose that cilastatin should be studied in clinical trials as a potential therapy for COVID-19. The current understanding of the drug mechanism of action suggests that it may both decrease viral entry and consequently viral replication, and additionally may protect from the deleterious consequences of the cytokine storm observed in severe COVID-19. Indeed, a clinical trial of the Fas ligand… Leer más »Cilastatin: a potential treatment strategy against COVID-19.