Publicaciones

Nanotechnology as a New Therapeutic Approach to Prevent the HIV-Infection of Treg Cells.

Didiana Jaramillo-Ruiz, Francisco Javier De La Mata, Rafael Gómez, Rafael Correa-Rocha, M Ángeles Muñoz-Fernández.

PLoS One. 2016 Jan 19;11(1):e0145760. eCollection 2016. DOI: 10.1371/journal.pone.0145760

This is the first work showing that the in vitro use of anionic dendrimers prevent the HIV-1 replication and the infection of expanded Treg cells in culture, which raises the possibility to use Treg cells therapeutically in HIV-1-infected subjects.

HIV-1 induces B-cell activation and class switch recombination via spleen tyrosine kinase and c-Jun N-terminal kinase pathways.

Ana Judith Perisé-Barrios, Rafael Correa-Rocha, Susana Alvarez, Maria Angeles Muñoz-Fernandez, Marjorie Pion.

AIDS 2014 Oct 23;28(16):2365-74.

These data provide the first evidence that SYK/BCR activation was the first step for B-cell activation and CSR mechanism after HIV-1 stimulation in a T-cell-free contex

HIV-1 induces B-cell activation and class switch recombination via spleen tyrosine kinase and c-Jun N-terminal kinase pathways.

Gema Méndez-Lagares, Didiana Jaramillo-Ruiz, Marjorie Pion, Manuel Leal, M A Muñoz-Fernández, Yolanda M Pacheco, Rafael Correa-Rocha.

J Acquir Immune Defic Syndr . 2014 Mar 1;65(3):278-82. DOI: 10.1097/QAI.0000000000000092

Our results argue for an impaired capacity of Treg to sense the expansion of activated T cells in HIV-infected patients that could contribute to the immune deregulation.

Low thymic output, peripheral homeostasis deregulation, and hastened regulatory T cells differentiation in children with 22q11.2 deletion syndrome.

Sara Ferrando-Martínez, Raquel Lorente, Dolores Gurbindo, Ma Isabel De José, Manuel Leal, Ma Angeles Muñoz-Fernández, Rafael Correa-Rocha.

J Pediatr. 2014 Apr;164(4).Epub 2014 Jan 23.

Objective: To perform an extensive analysis of the immune status of asymptomatic children with the 22q11.2 deletion syndrome, with special emphasis on the regulatory T cells (Treg) population.

Induction of Treg cells after oral immunotherapy in hen’s egg-allergic children.

Victoria Fuentes-Aparicio, Elena Alonso-Lebrero, Lidia Zapatero, Sonsoles Infante, Raquel Lorente, M Ángeles Muñoz-Fernández, Rafael Correa-Rocha.

Pediatr Allergy Immunol  2014 Feb;25(1):103-6. Epub 2013 Oct 7. DOI: 10.1111/pai.12137

Induction of Treg cells after oral immunotherapy in hen's egg-allergic children.

HIV infection of human regulatory T cells downregulates Foxp3 expression by increasing DNMT3b levels and DNA methylation in the FOXP3 gene.

Marjorie Pion, Didiana Jaramillo-Ruiz, Alberto Martínez, M Angeles Muñoz-Fernández, Rafael Correa-Rocha.

AIDS 2013 Aug 24;27(13):2019-29.  DOI: 10.1097/QAD.0b013e32836253fd

Objective: Regulatory T cells (Tregs) play an important role in infections modulating host immune responses and avoiding overreactive immunity. The mechanisms underlying their action in HIV-infected patients have not been well established. HIV can infect Treg, but little is known about the effects of the infection on Treg phenotype and function. The objective of this study was to investigate whether in-vitro HIV infection modifies the phenotype and suppressive capacity of Treg cells.

Oral immunotherapy in hen’s egg-allergic children increases a hypo-proliferative subset of CD4+ T cells that could constitute a marker of tolerance achievement.

Victoria Fuentes-Aparicio, Elena Alonso-Lebrero, Lidia Zapatero, Sonsoles Infante, Raquel Lorente, Ma Ángeles Muñoz-Fernández, Rafael Correa-Rocha.

Immunol . 2012 Nov;23(7):648-53. Epub 2012 Jul 26. DOII: 10.1111/j.1399-3038.2012.01333.x

Background: Food allergy affects a significant number of children and its prevalence, and persistence is undergoing an important increase in the last years. Specific oral tolerance induction (SOTI) is a promising therapy for food allergy. However, little is known about the immune mechanisms implicated in the desensitization to allergens. Our purpose was to study which immune parameters are modified during the process of tolerance achievement with the goal of identifying markers of tolerance induction.