En el pasado Congreso Nacional de la Sociedad Española de Inmunología celebrado del 24 al 26 de marzo de 2021, Sergio Gil Manso recibió el premio a la mejor comunicación oral por su trabajo desarrollado en la Caracterización y funcionalidad de timocitos humanos modificados genéticamente para expresar FOXP3 mediante lentivectores.
Esther Chamorro-de-Vega, Carmen-Guadalupe Rodriguez-Gonzalez, Silvia Manrique-Rodríguez, Elena Lobato-Matilla, Felix García-Moreno, Maria Olmedo, Rafael Correa-Rocha, Maricela Valerio, Teresa Aldámiz-Echevarria, Marina Machado, Milagros Sancho-Gonzalez, Juan Carlos Lopez-Bernaldo-de-Quirós, Paula Ruiz-Briones, Rosa Romero-Jiménez, Camino Sarobe-González, Alvaro Gimenez-Manzorro, Roberto Collado-Borrell, Cecilia M Fernandez-Llamazares, Jose Luis Revuelta-Herrero, Beatriz Somoza-Fernandez, Sebastian Garcia-Sanchez, Irene Taladriz-Sender, Emilio Bouza, Ana Herranz, Patricia Muñoz &Maria Sanjurjo. Expert Review of Clinical Pharmacology – Volume 14, 2021 DOI:10.1080/17512433.2021.1875819 Abstract Background: We report the long-term outcomes, changes in laboratory parameters, the incidence of secondary nosocomial infections and treatment cost of a Spanish cohort of patients with severe COVID-19 that received tocilizumab (TCZ). Methods: Retrospective cohort… Leer más »Clinical course of severe patients with COVID-19 treated with tocilizumab: report from a cohort study in Spain.
Isabelle Meyts, Giorgia Bucciol, Isabella Quinti, Bénédicte Neven, Alain Fischer, Elena Seoane, Eduardo Lopez-Granados, Carla Gianelli, Angel Robles-Marhuenda, Pierre-Yves Jeandel, Catherine Paillard, Vijay G Sankaran, Yesim Yilmaz Demirdag, Vassilios Lougaris, Alessandro Aiuti, Alessandro Plebani, Cinzia Milito, Virgil Ash Dalm, Kissy Guevara-Hoyer, Silvia Sánchez-Ramón, Liliana Bezrodnik, Federica Barzaghi, Luis Ignacio Gonzalez-Granado, Grant R Hayman, Gulbu Uzel, Leonardo Oliveira Mendonça, Carlo Agostini, Giuseppe Spadaro, Raffaele Badolato, Annarosa Soresina, François Vermeulen, Cedric Bosteels, Bart N Lambrecht, Michael Keller, Peter J Mustillo, Roshini S Abraham, Sudhir Gupta, Ahmet Ozen, Elif Karakoc-Aydiner, Safa Baris, Alexandra F Freeman, Marco Yamazaki-Nakashimada, Selma Scheffler-Mendoza, Sara Espinosa-Padilla, Andrew R Gennery, Stephen Jolles, Yazmin Espinosa, M Cecilia Poli, Claire Fieschi, Fabian Hauck, Charlotte Cunningham-Rundles, Nizar Mahlaoui, IKlaus Warnatz, Kathleen E Sullivan, Stuart G Tangye. J Allergy Clin Immunol 2021 Feb;147(2):520-531. DOI: 10.1016/j.jaci.2020.09.010 Abstract Background: There is uncertainty about the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in individuals with rare inborn errors… Leer más »Coronavirus disease 2019 in patients with inborn errors of immunity: An international study.
Jacobo López-Abente, Marta Martínez-Bonet, Esther Bernaldo-de-Quirós, Manuela Camino, Nuria Gil, Esther Panadero, Juan Miguel Gil-Jaurena, Maribel Clemente, Simon Urschel, Lori West, Marjorie Pion and Rafael Correa-Rocha. Sci Rep 2021 Jan 12;11(1):827. DOI: 10.1038/s41598-020-80567-9 Abstract CD25, the alpha chain of the IL-2 receptor, is expressed on activated effector T cells that mediate immune graft damage. Induction immunosuppression is commonly used in solid organ transplantation and can include antibodies blocking CD25. However, regulatory T cells (Tregs) also rely on CD25 for their proliferation, survival, and regulatory function. Therefore, CD25-blockade may compromise Treg protective role against rejection. We analysed in vitro the effect of basiliximab (BXM) on the viability, phenotype, proliferation and cytokine production of… Leer más »Basiliximab impairs regulatory T cell (TREG) function and could affect the short-term graft acceptance in children with heart transplantation.
María Ángeles González-Nicolás, Cristian González-Guerrero, Verónica Astrid Pérez-Fernández, Alberto Lázaro. Clinical Kidney Journal, Volume 13, Issue 5, October 2020, Pages 903–905. DOI: 10.1093/ckj/sfaa193 Based on the preclinical evidence of kidney and lung protection in the context of endotoxemia as presented in this letter. We propose that cilastatin should be studied in clinical trials as a potential therapy for COVID-19. The current understanding of the drug mechanism of action suggests that it may both decrease viral entry and consequently viral replication, and additionally may protect from the deleterious consequences of the cytokine storm observed in severe COVID-19. Indeed, a clinical trial of the Fas ligand… Leer más »Cilastatin: a potential treatment strategy against COVID-19.
Un equipo de investigadores de los hospitales Gregorio Marañón y Niño Jesús ha identificado una alteración en el sistema inmune de una paciente de tan sólo nueve meses con ictiosis, un grupo de enfermedades raras que provocan alteraciones muy graves en la piel y que pueden producir infecciones recurrentes y un retraso del crecimiento en los niños afectados. El descubrimiento, que ha sido publicado en la revista “New England Journal of Medicine”, se ha basado en la identificación de una alteración en el sistema inmune de una niña de 9 meses, lo que ha permitido un tratamiento específico para “bloquear… Leer más »Investigadores de los Hospitales Gregorio Marañón y Niño Jesús descubren un tratamiento para un tipo de ictiosis.
El proyecto, que cuenta con una inversión de 5 millones de euros, tiene como objetivo comprender mejor el funcionamiento de la respuesta inmunitaria frente al SARS-CoV-2, para desarrollar terapias celulares con linfocitos T que actúen frente a la infección por SARS-CoV-2 y terapias con células T reguladoras (Treg) para neutralizar la hiper-activación inmune responsable del empeoramiento de los pacientes COVID-19. El Laboratorio de Inmuno-regulación, liderado por Rafael Correa Rocha, del Hospital General Universitario Gregorio Marañón participa en un consorcio europeo de hospitales coordinado por el Clínic-IDIBAPS con el apoyo de la empresa Cellnex Telecom que impulsa la investigación sobre inmunoterapias… Leer más »El Marañón participa en un proyecto europeo de inmunoterapia celular frente a la COVID-19.
Elena Monzón Manzano, María Teresa Álvarez Román, Raúl Justo Sanz, Hosvan y Fernández Bello, Diana Hernández, Mónica Martín Salces, Larissa Valor, Isabel Rivas Pollmar, Nora V. Butta1 and Víctor Jiménez Yuste. British Society for Haematology and John Wiley & Sons LtdBritish Journal of Haematology, 2020, 189, 943–953 – 16 january 2020. DOI: 10.1111/bjh.16459 Abstract Multifactorial mechanisms leading to diminished platelet counts in immune thrombocytopaenia (ITP) might condition the ability of patients with ITP to respond to treatments. Examining their platelet and immune features, we aimed to detect singular characteristics of patients with ITP who do not respond to any treatment. We… Leer más »Platelet and immune characteristics of immune thrombocy-topaenia patients non-responsive to therapy reveal severeimmune dysregulation.
Elena Blázquez-López, Félix Royo, Elena Vázquez-Ogando, Francisco Javier Cubero, Raquel Herrero, Laura Moreno, José A. Lorente, Angel Cogolludo, Rafael Correa, Marjorie Pion, Yulia Nevzorova, Johanna Sierra, Marta Puerto, Ismael Ranz, Agustin Albillos, Jaime Bosch, Rafael Bañares, Jordi Gracia-Sancho, Juan Falcon-Perez, Javier Vaquero. Journal of Hepatology 2020 vol. 73 | S123–S400 DOI:10.1016/S0168-8278(20)30952-1 ABSTRACT: THU 168 Background and Aims: Most information about hepatocytederived exosomes and extracellular vesicles (EVs) and their role in health and disease derives from cell culture experiments, which do not represent the complexity of whole organisms. The lineage reporter mT/mG mouse strain allows the generation of mice that express… Leer más »ABSTRACT: Novel in vivo tracing of the hepatocyte origin of extracellular vesicles in mice with experimental liver disease.
L M Nieto-Benito, Beatriz Berenguer-Fröhner, Verónica Parra-Blanco, Minia Campos-Domínguez. Rev Chil Pediatr 2020 Feb;91(1):99-104. Epub 2019 Dec 3. DOI: 10.32641/rchped.v91i1.1303. Abstract Introduction: Bednar tumor is a rare low-grade sarcoma considered the pigmented variant of dermatofibrosarco ma protuberans (DFSP). Objective: To describe the clinical and histopathological characteristics, treatment and evolution of this rare neoplasm. Clinical case: A 9-year old female presented with a 2-year history of an indurated, asymptomatic papule on the back of her fourth left toe. The incisio nal biopsy was compatible with pigmented DFSP. The immunohistochemical study showed intense positivity for CD34 throughout the lesion, with negative factor XIIIa. We complemented the study with molecular… Leer más »Pigmented Dermatofibrosarcoma Protuberans: Description of a pediatric case.
